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Toremifene citrate89778-27-8
Product Detailed
Related Categories:Healthcare Supplies
Product Details
Basic Info.
Model NO.:89778-27-8
CAS:89778-27-8
Purity:99% Min.
Appearance:Powder
Molecular Formula:C32h36clno8
Molecular Weight:598.08
Einecs:N/a
Export Markets:Global
Additional Info.
Packing:Disguised Package
Standard:99% min.
Origin:China
HS Code:3001901000
Production Capacity:5000kgs
Product Description
Toremifene citrate
Skype:silvialiu
Email Address:[email protected]
http//www.raw-steroid-powder.com
CAS: 89778-27-8
MF: C32H36ClNO8
MW: 598.08
Chemical Properties White-to-Off-White Solid
Usage anesthetic
Usage An antiestrogen and antineoplastic. Nonsteroidal antiestrogen structurally similar to Tamoxifen.
Toremifene citrate Description:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there.
Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular). This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid cycle, such as improving and shifting cholesterol levels into a more favorable range.
Toremifene citrate Specification:
Test items Quality requirements Results
Description White or like white crystalline powder White crystalline powder
Solubility Freely soluble in pyridine and acetic acid(100), sparingly soluble in methanol, slightly soluble in ethanol, very slightly soluble in water, and practically insoluble in diethyl ether Freely soluble in pyridine and acetic acid(100), sparingly soluble in methanol, slightly soluble in ethanol, very slightly soluble in water, and practically insoluble in diethyl ether
Melting point 159~163ºC 159.0~160.5ºC
Identification
(a)Positive reaction Must comply Complies
(b)Positive reaction Must comply Complies
(c) UV There is the strongest absorption at the wavelength of 234~238nm and 275~278nm. There is the strongest absorption at the wavelength of 236.8nm and 276.2nm.
(d) IR There is absorption at 1741, 1703, 1585, 1241 and 706cm-1 . There is absorption at 1741, 1703, 1585, 1241 and 706cm-1 .
Purity
(a) Relative substances
E-isomer ≤0.5% 0.001%
Total relative substances ≤1.0% 01%
(b)Heavy metals ≤10ppm <10ppm
Loss on drying ≤1.0% 0.1%
Toluene ≤0.089% 0.0002%
Ethanol ≤0.5% 0
Acetone ≤0.5% 0.21%
Tetrahydrofuran ≤0.072% 0.0001%
Chlorobenzen ≤0.036% 0
Benzene ≤0.0002% 0
Residue on ignition ≤0.1% 0.04%
Assay ≥98.5% (Calculated by C26H28ClNO .C6H8O7)
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